Gastrointestinal pathogens refer to various microorganisms capable of invading and colonizing the human gastrointestinal tract (including the stomach, small intestine, and large intestine), causing gastrointestinal dysfunction and diseases (such as diarrhea, vomiting, gastritis, enteritis, etc.) by damaging the mucosa, secreting toxins, or inducing inflammatory responses. They are primarily transmitted through the fecal-oral route, often via contaminated food, water, or direct person-to-person contact. Common gastrointestinal pathogens mainly include four categories: viruses, bacteria, parasites, and fungi.
Leveraging its proprietary TargetSeq® liquid-phase probe hybridization capture technology and unique microbial probe design strategies, iGeneTech is dedicated to addressing critical issues such as viral variant monitoring, low-abundance viral sample detection, and host origin tracing. The company has currently launched multiple whole-genome detection kits for gastrointestinal pathogens.
| Product Name | Pathogen Species Details | txid | Coverage Size | Number of Reference Sequences | Number of Probes |
| Norovirus Panel | Norovirus GI | 122928 | 7.7 kb | 1533 | 32252 |
| Norovirus GII | 122929 | 7.6 kb | |||
| Norovirus GIV | 262897 | 7.9 kb | |||
| Rotavirus Panel | Rotavirus A | 28875 | 18.6 kb | 1109 | 48809 |
| Rotavirus B | 28876 | 17.5 kb | 811 | ||
| Rotavirus C | 36427 | 17.9 kb | 1831 | ||
| Enterovirus Panel | Enterovirus A | 138948 | 7.4 kb | 2763 | 143791 |
| Enterovirus B | 138949 | 866 | |||
| Enterovirus C | 138950 | 1562 | |||
| Enterovirus D | 138951 | 915 | |||
| Enterovirus A71 | 39054 | 1235 | |||
| Enterovirus D68 | 42789 | 862 | |||
| Helicobacter Pylori Panel | Helicobacter pylori | 210 | 1.7 Mb | 409 | 2237317 |
| Vibrio Cholerae Panel | Vibrio cholerae | 666 | 4.1 Mb | 144 | 322030 |
| Salmonella Panel | Salmonella | 590 | 6180 | 903318 |
| Product Name | Set | Cat. No |
| Norovirus Panel | 16 rxn | PH2001391 |
| 24 rxn | PH2001395 | |
| 96 rxn | PH2001392 | |
| Rotavirus Panel | 16 rxn | PH2002361 |
| 24 rxn | PH2002365 | |
| 96 rxn | PH2002362 | |
| Enterovirus Panel | 16 rxn | PH2001871 |
| 24 rxn | PH2001875 | |
| 96 rxn | PH2001872 | |
| Helicobacter Pylori Panel | 16 rxn | PT1014261 |
| 24 rxn | PT1014265 | |
| 96 rxn | PT1014262 | |
| Vibrio Cholerae Panel | 16 rxn | PH2001441 |
| 24 rxn | PH2001445 | |
| 96 rxn | PH2001442 | |
| Salmonella Panel | 16 rxn | PT1014321 |
| 24 rxn | PT1014325 | |
| 96 rxn | PT1014322 |
1．Yu F, Ma N, Zhang X, et al. Comprehensive investigating of cytokine and receptor related genes variants in patients with chronic hepatitis B virus infection. Cytokine. 2018 Mar;103:10-14.
2．Pang X, Ren L, et al. Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing. Natl Sci Rev. 2020 Oct 23;7(12):1861-1864.
3．Du P, Ding N, et al. Genomic surveillance of COVID-19 cases in Beijing. Nat Commun. 2020 Oct 30;11(1):5503.
4．Chen C, Li J, et al. MINERVA: A Facile Strategy for SARS-CoV-2 Whole-Genome Deep Sequencing of Clinical Samples. Mol Cell. 2020 Dec 17;80(6):1123-1134.e4.
5．Xu Y, Kang L, et al. Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence. J Genet Genomics. 2020 Oct 20;47(10):610-617.
6．Wu X, Ning C, et al. A 3,000-year-old, basal S. enterica lineage from Bronze Age Xinjiang suggests spread along the Proto-Silk Road. PLoS Pathog. 2021 Sep 21;17(9):e1009886.
7．Zhang J, Ding N, et al. Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak. Innovation (Camb). 2021 May 28;2(2):100099.
8．Li J, Du P, et al. Two-step fitness selection for intra-host variations in SARS-CoV-2. Cell Rep. 2022 Jan 11;38(2):110205.
9．Song S, Li C, et al. Genomic Epidemiology of SARS-CoV-2 in Pakistan. Genomics Proteomics Bioinformatics. 2021 Oct;19(5):727-740.
10．Zhang J, Tian X, et al. Feasibility and Accuracy of Menstrual Blood Testing for High-risk Human Papillomavirus Detection With Capture Sequencing. JAMA Netw Open. 2021 Dec 1;4(12):e2140644.
11．Li P, Ke Y, et al. Targeted screening of genetic associations with COVID-19 susceptibility and severity. Front Genet. 2022 Nov 30;13:1073880.
12．Pu R, Liu W, et al. The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma. Front Oncol. 2022 Feb 10;12:836517.
13．Zhang M, Zhang H, et al. Liver biopsy of chronic hepatitis B patients indicates HBV integration profile may complicate the endpoint and effect of entecavir treatment. Antiviral Res. 2022 Aug;204:105363.
14．Shen C, Li Y, et al. HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation. Nat Commun. 2022 Nov 30;13(1):7368.
15．Liu W, Cai S, et al. HBV preS Mutations Promote Hepatocarcinogenesis by Inducing Endoplasmic Reticulum Stress and Upregulating Inflammatory Signaling. Cancers (Basel). 2022 Jul 4;14(13):3274.
16．Feng XL, Yu D, et al. Characteristics of replication and pathogenicity of SARS-CoV-2 Alpha and Delta isolates. Virol Sin. 2022 Dec;37(6):804-812.
17．Wang Y, Nan X, et al. Consumption of Supplementary Inulin Modulates Milk Microbiota and Metabolites in Dairy Cows with Subclinical Mastitis. Appl Environ Microbiol. 2022 Feb 22;88(4):e0205921.
18．Lang B, Cao C, et al. Genomic alterations related to HPV infection status in a cohort of Chinese prostate cancer patients. Eur J Med Res. 2023 Jul 17;28(1):239.
19．Adeola AC, Luka PD, et al. Target capture sequencing for the first Nigerian genotype I ASFV genome. Microb Genom. 2023 Jul;9(7):mgen001069.
20．Sun B, Andrades Valtueña A, et al. Origin and dispersal history of Hepatitis B virus in Eastern Eurasia. Nat Commun. 2024 Apr 5;15(1):2951.
21．Wang Z, Liu C, et al. Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines. BMC Genomics. 2024 Feb 20;25(1):198.
22．Yang Z, Zeng J, et al. Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy. Virol Sin. 2024 Aug;39(4):655-666.
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